December 2023
Congratulations to Sarah for her collaborative paper published with the lab of Dr. Deyou Zheng (link). The article investigates the functional contribution and clinical implication of cancer-associated fibroblasts in glioblastoma.
Congrats to Jenny as well for her collaboration with Dr. Maureen Charron, where they published a proteomics analysis of human cord plasma revealing protein signatures associated with intrauterine growth restriction (link).
Simone presents a seminar with the latest lab updates to the CelVivo webinar series (video below).
November 2023
Sorry for the long silence in updating the website. The webmaster had to go through a painful surgery, but we are back on track!
Lab website is updated with new pictures from the conferences in South Africa (link) and Greece (link)!
A collaboration with the Santulli lab (Einstein) shows that “Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling” (link).
Congrats to Jenny for her collaborative article with Dr. Shudan Wang and team on urine proteomics in Lupus Nephritis patients (link).
Simone will give a webinar in early December sponsored by CelVivo on how we use 3D spheroids to model aging (link for registration).
The program BEYOND ALBERT published a video summarizing this summer work of Raisa and her class. So sweet! Thank you everyone for working together with the next generation of scientists!
Something new is boiling in the lab! We received the new timsTOF HT with PASER and it is currently being installed. This instrument replaces our older Orbitrap Velos, which has done great things for science, but it is now ready for retirement.
October 2023
Simone presents at the SACCMA conference in South Africa the progress we made with the analysis of 3D cells (pictures here). Thank you so much to Dr. Chrisna Gouws for the invitation!
Simone presents at the IUBMB conference in Crete, Greece (pictures here). Lots of exciting news on chromatin biology and proteomics of the nucleus. Thank you so much to Dr. Constance Alabert and organizing committee for the invitation!
September 2023
Collaboration article published with the team of Dr. Kabirul Islam (University of Pittsburgh) out today in the Journal of the American Chemical Society (link)!
The Einstein-Montefiore Cancer Center has been awarded the highest recognition of the NCI. We are now a Comprehensive Cancer Center! Congrats to all the members, and our Director Dr. Edward Chu for making this happen!
The lab says goodbye to Raisa. We will miss her very much! A huge thank you once again to the BEYOND Einstein program for organizing such a nice summer experience for our high school students. As well, a big thank you to Sarah and Stephanie who have been directly mentoring her in all steps of her project.
Congrats to Jenny for another successful collaboration just published in iScience (link). Thank you to Dr. Betsy Herold lab for including us in this very interesting study on the placental transfer of antibodies.
Simone is interviewed by Epigentek on the topic of “Therapeutic Targeting of Histone Modifications” (link).
August 2023
Congratulations to Yan, who had his abstract accepted for an oral presentation at the CASSS conference!
Congratulations to Edwin as well, who will present at the IMaSS symposium "Proteomics and metabolomics for Biomarker Development in Cardiovascular-related diseases" in Milan!
Congratulations to Jenny; her collaborative paper is out in GLIA (link)! Thank you to the lab of Dr. Richard Stanley for the great shared project.
The high school program BEYOND Einstein visits the Sidoli lab for learning about mass spectrometry and chromatin biology.
Some great news funding-wise. The lab has received NIH funding for a collaboration with the laboratory of Stephen Sykes (WashU in St. Louis), and DoD funding for a collaboration with the lab of Sam Bakhoum (MSKCC). Thank you to our collaborators for sharing their resources for working with us!!
New instruments in the lab! The lab is equipped with a new laser microdissector, and a new microscope for the cell lab.
The lab receives as generous donation a super-awesome cheesecake from an admirer who clearly thinks very highly of us :-)
July 2023
Simone gives a seminar to the company HotSpot Therapeutics to discuss methods in mass spectrometry to study protein structure and modifications. A special thank you to Dr. Eric Chan for the invitation!
New publication from the lab: “Semi-Automated Phenotypic Analysis of Functional 3D Spheroid Cell Cultures” (Journal of Visualized Experiments). Congrats to Stephanie and Dejauwne for driving the manuscript, and a special thank you to our friends at CelVivo for helping (link).
Congratulations to Jenny for submitting her first-author publication (currently in revision) with the lab of Dr. Herbert Lachman (Einstein). The pre-print is available here (link).
A new collaboration with the Shafit-Zagardo lab (Einstein) is published in Cells (link). Well done to Sarah for driving this collaboration!
New collaboration with the Dawlaty lab (Einstein) on the non-enzymatic role of Tet2 is published in iScience (link). Congratulations to Julio Flores, including for his recent PhD!
New paper on de novo heterochromatin assembly in collaboration with the Groth (University of Copenhagen) and Taneja (Erasmus MC Cancer Institute, Rotterdam) labs published in Nature Cell Biology (link).
The lab says goodbye to Julie. Julie spent two years into our team, working at projects that span from protein oxidation footprinting to quantification of antibiotics degradation to identify resistant strains of Klebsiella. Thank you for all your hard work, and best of luck with the continuation of your career!
The lab says goodbye to Laura as well, who will return to Belgium to complete her PhD. They have been 6 months of very intense work, from the epigenetics histone clock to single cell proteomics. We are very grateful for all the energy you put into our team. Looking forward to seeing your next steps!
From today, Yan is officially a Sidoli lab member. He has been part of our team for a very long time, but this has now become his official appointment.
The lab welcomes Raisa Karim to the team!! Raisa is a high school student who will work with us for 2 months under the program BEYOND Einstein. We will work together on 3D cells and anti-aging drugs!
Congratulations to Jenny for her collaboration with the lab of Dr. Rajat Singh (UCLA) published in Nature Cell Biology (link). The manuscript describes how fasting or lipid availability stimulates mTORC2 activity.
It turns out that Laura is also an artist! She left us a very cool painting as goodbye present for the team (image below).
June 2023
New collaboration with the lab of Kartik Chandran (Einstein) is published in Science Translational Medicine (link). Well done to Yan for the proteomics analysis!
Congratulations to Dejauwne for having his review article “The role of histone H3 lysine demethylases in glioblastoma” accepted for publication (link)! Interesting trivia: this the 150th peer-reviewed publication for Simone.
Congrats to Stephanie as well for her collaborative work with the lab of Sam Bakhoum (MSK) published in Nature (link). The manuscript shows how chromosomal instability is sequestered in micronuclei.
The lab comes back from an awesome ASMS conference! We also managed to visit the NASA Space Center. Here is a dedicated album we saved on the website (link).
The lab is on its way to the ASMS conference! Great job to Laura who will give an oral presentation, and to Yan and Carlos who will present their posters.
Congratulations to Dejauwne who got accepted to participate to the very prestigious course in Cold Spring Harbor named “Chromatin, Epigenetics & Gene Expression”. This is a 3-weeks intense course training on methodologies to study gene regulation, chromatin structure and dynamics. Dejauwne also got an award to reduce the cost for registration; excellent work!!
Well done to Ronnie as well, who participates to the EMBL Symposium on “The Ageing Genome” (Heidelberg, Germany)
Simone represents the Einstein Nathan Shock Institute at the AGE 2023 conference (link) in Oklahoma City, where he presented our most recent updates on chromatin regulation of individuals with exceptional longevity.
A quick update on our collaborations in BioRxiv: Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal (with the Huangfu lab, MSKCC) (link); Monomethylation of Lysine 27 at Histone 3 Confers Lifelong Susceptibility to Stress (with the Nestler lab, Mount Sinai) (link).
Simone participates once again to the EMBO course for the “Characterisation of post-translational modifications in cellular signalling” in Denmark (link). Thank you once again to the organizers for the invitation!
Simone will be one of the invited speakers at the IUBMB Focused Meeting on Integrative Omics of Nuclear Functions (poster below).
May 2023
Sarah, Laura and Simone participate to the Chromatin Club of Rutgers University (New Jersey). A special thank you to Sam Gu for inviting us!
Cassia Michael joins the Sidoli lab for her third rotation! Welcome to the team (link)!
Congratulations to Stephanie for her new collaborative paper with Dr. Payel Sen lab (NIA) on aging chromatin: “A hyper-quiescent chromatin state formed during aging is reversed by regeneration”, published in Molecular Cell (link).
By the way, the collaborative paper with the lab of Dr. Payel Sen made it to the cover of the Molecular Cell issue (image below)!
And congratulations to Stephanie again for the collaboration published in Biochemical Pharmacology titled: “Orally administered sodium nitrite prevents the increased α-1 adrenergic vasoconstriction induced by hypertension and promotes the S-nitrosylation of calcium/calmodulin-dependent protein kinase II” (link). Thank you for working with us, Sibinga (Einstein) and Tanus-Santos (U of Sao Paulo) labs!
The lab is recorded by the TV troupe from Above York Media for a documentary on aging (images below).
April 2023
The work of our rotation student Megan DeMouth became a collaborative article with Dr. Myriam Gorospe from the NIA! The paper proposes that DPP4-regulated factors could be exploited therapeutically to reduce senescent cell function, reverse senohemostasis, and improve vascular disease (link).
Well done to Stephanie for a new collaboration with Betsy Herold’s lab (Einstein) accepted in the Journal of Clinical Investigation. The paper is titled: “HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal” (link).
A new collaboration with our awesome new addition to the Department, Dr. Seiya Kitamura, is published in ACS Chemical Biology (link).
Simone will be a keynote speaker at the next SACCMA conference on 3D cell culture and organoids in Potchefstroom (South Africa) this October (link).
Sarah presents at the Department Work-In-Progress!
The lab invites Dr. Italo Tempera (Wistar Institute in Philadelphia) to visit Einstein. Thank you for the awesome seminar, all the interactions, and the great evening around the wonders of NYC (in the picture, Bryant Park)!
One fun trivia: the Einstein-Montefiore Health System is the new official hospital for the New York Yankees (link to the news)!
March 2023
Carlos, Laura, Yan and Simone come back from a great Epigenetics Symposium in Philadelphia (link). This is becoming a yearly appointment, and we intend to keep it. Lots of fantastic speakers and interactions this year too! Laura and Yan also presented their posters.
Congratulations to Laura for receiving a notification for accepted oral at the ASMS conference this year!! Congratulations to Carlos and Yan as well for having their poster accepted for presentation! Houston, here we come!
Ronnie and Simone return from a very successful US HUPO conference. Ronnie and his single cells were very popular! In addition, lots of great science, including emerging proteomics methods that do not utilize mass spectrometry.
A great new collaboration with our friend Dr. Richard Lauman from the labs of Ben Garcia (WashU in St. Louis) and Matt Weitzman (Children’s hospital of Philadelphia). Richard showed some advanced methodology to study intact tRNA by mass spectrometry (link).
Congratulations to Dr. Mu Feng as well (Vern Schramm lab, Einstein) for this great paper on treatment and resistance of H. Pylori (link).
A brief update on our pre-prints from BioRxiv as well. Great job to Julie and Yan for their collaboration with the Sen lab (NIA) on DNA modifications in aging (link). Well done to Stephanie for her other collaboration with the Sen lab (NIA) on hyper-quiescent chromatin (link). Finally, a shout out for Ronnie for his collaboration with the lab of Danwei Huangfu (MSKCC) on CTCF loops in cell state transition (link).
Simone is co-organizing a new event of the Italian Mass Spectrometry Society (IMaSS). This time the title is “Extreme Chromatography Workshop” (link). Consider attending; it will be held in the beautiful Rome (Italy) in May.
Simone visits the institute Il Monzino (Milan, Italy) for a seminar, and for sharing projects related to cardiology, aging and chromatin biology.
February 2023
Congratulations to Dejauwne for being awarded this year's Kwok scholarship!! The Kwok scholarship is a funding mechanism for diversity/minorities studying internal medicine.
Well done to Laura for volunteering to present at our Department Work in Progress meeting. She just arrived and she is already discussing her project with big crowds; we are impressed!
Thank you to CelVivo for their seminar at Einstein this month! Great work of Reeham and Louis, and thank you to all the attendees to listen to the great updates on the ClinoStar.
The lab submits three abstracts to this year’s ASMS. We will bring a smaller crowd to Houston compared to Minneapolis, but it will be a lot of fun regardless. More news soon regarding their acceptance.
Simone will teach in a new department course called “Chemical Biology” (most likely starting this fall). We will train students on click chemistry, high throughput mass spectrometry and affinity proteomics.
Our Einstein Cancer Center announced a new budget of $100M for the next round of recruits of new professors and labs. If you are reading this and you want to start a lab at Einstein, feel free to inquire and ask us questions.
This month, the Proteomics Core will present at the “Pathway to Success” seminar series at Einstein. It is a monthly event where a Core from Einstein illustrates its achievements, latest innovations, and how to collaborate. A special thank you to Drs. Louis Weiss and Kartik Chandran to present examples of our successful collaborations.
A new exciting collaboration with the laboratory of Dr. Julie Secombe (Einstein) is published in Epigenetics & Chromatin (link).
January 2023
Welcome back everyone! Best wishes for a 2023 full of good science and great life. A few tips in case you are looking to meet us in person this year; the lab is already planning to attend the US HUPO conference (Chicago) in March, the Epigenetics Symposium (Philadelphia) in March, and the ASMS conference (Houston) in June. Simone will be also at the AFAR Grantee meeting (Santa Barbara) in June and the Integrative Omics of Nuclear Functions meeting (Crete, Greece) in October. More things will surely come up… Meanwhile, we are already warming up the engines!
Welcome to Laura Corveleyn, who crossed the Atlantic Ocean from UGent (Belgium) to the Sidoli lab (link).
A new collaboration with the University of Parma (Italy) identifying regulation of histone modifications upon methionine depletion is published in the journal Cancers (link).