December 2021
Summary of the year: We still live in difficult times, but the Sidoli lab has been fortunate this year. We were lucky that nobody got sick, and we got blessed by a lab blooming with new people, ideas and collaborative support. 5 new members joined our team: Dejauwne, Julie, Ronnie, Jazmine and Edwin (link). We published 3 new articles + 14 collaborative papers (link). We also have 16 manuscripts currently in the peer-review process. Our core and the research side (now almost undistinguishable) worked with 130 different collaborators, a new record for us. Finally, we are very grateful to our funding sources and collaborators, as we currently run the lab with 13 active grants (link). Thank you everyone for your support and friendship; a toast for a better year to come in every sense!
Congratulations to Eddie for the last paper of 2021. His work in collaboration with the lab of Dr. Johanna Daily (Einstein-Montefiore) demonstrates that levels of pipecolic acid in blood can dramatically impact the outcome of cerebral malaria (link).
The Orbitrap Exploris 480 is being installed in the lab!
Simone is awarded the 2022 Eastern Analytical Symposium Young Investigator Award!
New collaboration from Stephanie with the labs of Kathryn Wellen (UPenn) and Nate Snyder (Temple) out in Molecular Cell (link).
Thank you to Dr. Alessandro Gardini (The Wistar Institute in Philadelphia, link) for the virtual visit at Einstein and for the great seminar on the Integrator Complex).
November 2021
A new publication from the lab is accepted in MethodsX. Congratulations to Yan, Stephanie and Jenny for their protocol paper on high-throughput DNA modification analysis (link).
First baby from the Sidoli lab!!! Congratulations to Edwin and wife for the handsome Thomas!! Happy life to all of you!
The lab receives the new Orbitrap Exploris 480 with FAIMS (Thermo Scientific)! This will allow us for more sensitive proteomics (single cells), intact protein analysis (with the Biopharma module) and overall higher capacity for experiments.
The lab has expanded into a new room on the Ullmann building to accommodate the demand for more sit downs. 12 people in the lab and counting!
We received a surprise visit from our friends at CelVivo (images below).
October 2021
We will work on a new collaborative grant investigating “In vivo mechanisms mediating sickle cell vaso-occlusion and organ damage” (link). The grant was originally from our beloved Dr. Paul Frenette; a project so important that the NIH decided to award it anyway even though he could no longer work on it. We are part of the committee aiming to stand up to his legacy. A big thank you also to Dr. Libusha Kelly for taking up the responsibility of leading the project.
The Sidoli lab is now part of the new Einstein Institute of Neuroimmunology and Inflammation (link)!
Simone will give a guest lecture on chromatin and proteomics at Rutgers University. Thank you to Dr. Sam Gu for the invitation.
Simone is presenting at the 2021 AFAR Grantee Conference on October 5th!
Simone presents at the CelVivo webinar series on October 7th at 10 am (EST). Here is the registration link for who wants to attend: link.
Our institute received the visit of Dr. Jill Biden! Here is a video where important issues on breast cancer awareness is being discussed in our courtyard (link)
The lab hosts a virtual visit of Dr. Lluis Morey (University of Miami) (link). Thank you for the great presentation, and all the collaborative work!
Ronnie, Sarah and Jazmine participate to the lab declaration ceremony! Thank you guys for joining the Sidoli lab and for the amazing environment you contribute to create every day!
September 2021
Congratulations to Stephanie for her co-first author publication titled “A key silencing histone mark on chromatin is lost when colorectal adenocarcinoma cells are depleted in methionine by methionine gamma-lyase” (link).
Congratulations to Yan for being awarded the CASSS Next Generation Investigator Award!
The lab collaborates on a new grant with Dr. Danwei Huangfu (MSKCC) investigating gene regulatory networks governing early human lineage decisions. The project is part of a major initiative of the National Human Genome Research Institute (link).
Lab barbecue last weekend!
Stephanie presents her project at the Nathan Shock Institute work in progress, in front of a lot of world star aging scientists! (no pressure felt)
August 2021
Welcome back to Dejauwne in the lab! After one year of hard MD classes, Dejauwne is back to start his PhD project as shared student between our lab and the lab of Dr. Chandan Guha (link).
Thank you very much to Merck for sponsoring our collaboration to further optimize our high-throughput analysis of protein modifications via direct injection mass spectrometry. A big thank you to our old friend Dr. Anumita Saha for initiating the collaboration.
Nice collaboration of Yan with the laboratory of Dr. David Schechter, where they investigated the independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases (link).
Simone will present for the CelVivo seminar series on October 7th. Other great talks are in the program!
ScienceDaily (link) and EurekAlert! (link) highlight the collaborative work of the lab with the laboratory of Dr. Kartik Chandran on the crimean-congo hemorrhagic fever virus.
Congratulations to the lab for having 5 abstracts accepted for poster presentation at ASMS this year. Well done Stephanie, Jenny, Yan, Sarah and Carlos!
Well done to Stephanie! Another collaboration with Dr. Lluis Morey (University of Miami) shows how RING1B mediates gene expression by looping gene promoters and enhancers (link).
July 2021
Yan, Stephanie and Jenny published their work on high-throughput analysis of DNA modifications in Analytica Chimica Acta (link). Well done!
Happy birthday to Jenny, who got as present new bins for garbage recycling…
Congratulations to Ronnie for being awarded a T32 training grant from the Cellular and Molecular Biology and Genetics training program!
Welcome back to Ronnie Cutler to the lab! Ronnie has finished his rotations, and he decided to join our group as well as the team of Jan Vijg (link) for a joint PhD project exploring single cell somatic mutations and proteomics in aging.
Welcome to Julie Kim, a new research technician in the lab! She will work with the projects in collaboration with Relay Therapeutics as well as Deerfield.
June 2021
A big thank you to Dr. Louis Weiss for including us in his NIH R01 grant named “Microsporidia: invasion apparatus”! Microsporidia invade cells using a unique mechanism. Studies of the polar tube, a structure involved in invasion, and the mechanism by which microsporidia invade their host cells should help define new strategies for the management of these emerging pathogens.
The lab says goodbye to Steven Grudman at the end of his rotation. Thank you so much for all the work you did in developing new chromatographic strategies for small molecules. All the best for your PhD project with Andras Fiser!
Congratulations to Jenny for her collaborative paper with the Chandran lab, investigating protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever (link).
See our press release of the Catalyst Award we received from the Health Longevity Global Grand Challenge initiative (link).
The lab has a shared group meeting with Dr. Giorgio Oliviero, proteomics specialist from the University College Dublin.
A collaboration investigating the role of FGF-2 in cell cycle progression and the impact on oncogene-induced senescence is published in Molecular Omics (link).
A collaboration on the role of VAL1/2 in Arabidopsis with the laboratory of Scott Poethig is published in Plos Genetics (link). VAL1 and VAL2 are critical transcription factors necessary for the development of the plant.
May 2021
The lab is awarded an NIH S10 Shared Instrument Grant!! Thank you very much to the NIH for supporting the investigators at Einstein by reinforcing the proteomics equipment. Stay tuned to see our new Orbitrap Exploris 480 coming into the lab!
Stephanie presents her career path that led her to the Sidoli lab at PROC-PROSACOMCIENCIA.
Simone hosts Dr. Sam Gu from Rutgers (link bio), who gave a mind-blowing presentation on how small RNAs carry epigenetics inheritance across generations in C. elegans. Thank you for the virtual visit.
The lab welcomes Steven Grudman for his rotation in our group!
A big thank you to Megan DeMouth and Ronnie Cutler for their hard work during their rotation. We are very grateful for the contribution they gave to the lab, which helped moving forward our project on histone succinylation and chromatin of centenarians. Best of luck with your next adventure!
The lab is mentioned as one of the recipients of the Xseed award on the Deerfield website (link) and the Einstein newsletter (link). Thank you very much to Deerfield for the great opportunity!
April 2021
Stephanie is showing the 3D system and our direct injection platform to the committee of Dimension Sciences (video below).
We modified the section “Core Material” on the website to include resources for accessing our Core (link). This includes protocols, prices, documentation for grants and video tutorials for proteomics data analysis.
Surprise in the lab! Our new incubators to grow 3D cell culture are here! A big thank you to CelVivo; we are so looking forward to start our first culture in their ClinoStars.
Congratulations to Stephanie for being one of the finalists for the ScientistA award sponsored by Dimensions Sciences (link)!
The lab is very thankful to Dr. Wenjun Guo (Einstein) and the Department of Defense for including us in the grant investigating how tumor suppressor MLL3 mutations promote tumor infiltrating regulatory T and B cells.
Congratulations to Stephanie for her collaborative work with the laboratory of Dr. Danwei Huangfu published in Science (link). The project describes the protein QSER1 as protecting DNA methylation valleys from de novo methylation.
A collaboration with Dr. Lu and the Garcia lab is published on the Journal of the American Society for Mass Spectrometry (link). The article discusses how histone combinatorial codes are regulated during the cell cycle.
The lab welcomes Jazmine-Saskya Joseph as new rotation student!
Simone will give two lectures on proteomics data analysis in collaboration with the Italian Mass Spectrometry Society (IMASS). Live session is available for those who register on imass.it, or later available on the IMASS YouTube channel.
March 2021
A collaboration with Dr. Hope Kronman from the lab of Dr. Eric Nestler (Mount Sinai) is published in Nature Neuroscience (link)! A special thanks to Dr. Nestler, as he has been one of the very first financial supports of the group, helping us sponsor the “reactivation” of the Advion NanoMate!
The lab says goodbye to Kristen, as she is moving on to her next rotation. Thank you for all the hard work you did with our 3D cells and histone analysis!
The lab receives funding from the Xseed award (link) to develop an assay based on MALDI-MS to identify Klebsiella resistance in Montefiore patients. The project is in collaboration with the laboratories of Drs. Andras Fiser, Johanna Daily and John Blanchard. Thank you for the support!
Simone is interviewed by AFAR to celebrate the Sagol Network GerOmic award (link). Thank you again for the support for our aging research!
We have made another step towards creating a more-environmentally friendly lab. Sarah has optimized our histone preparation method to pickup multiple reagents using the same pipette tips. Moreover, our robot is now able to return used tips into their original racks for washing, rather than discarding them as used plastic (see demonstration below).
February 2021
We have THREE new people joining us by the end of the month! Thank you everyone for joining the team and working with us on chromatin proteomics. Edwin Yoo is a Cardiology fellow at Johns Hopkins Hospital, who will work as postdoc in our lab. Megan DeMouth and Ronald Cutler will be doing their PhD rotation in our lab (more details here).
Stephanie is selected for a lightning talk at the US HUPO 2021 conference! Congratulations!
Congratulations to our collaborators at Immagina BioTechnology for publishing on eLife their new kit AHARIBO (link). With this kit, we demonstrated that nascent proteomics can be performed with a quick enrichment using click chemistry, and potentially identify translates from non-coding RNA.
Simone will be one of the presenters at the online EMBO course for Quantitative Proteomics in early May (link). Check out the interesting program. The deadline for the application is March 8th.
Simone discusses with Dr. Elisa Ronga regarding the lab research and the innovations of Immagina BioTechnology (podcast link).
Yan presents his work on DNA modifications at the Department Seminar!
Simone gives three lectures at the “Introduction to proteomics” course at the Universidade de Brasilia, Brazil. Thank you to Dr. Wagner Fontes for the invitation.
The Sidoli lab receives The Sagol Network GerOmic Award!! Thank you very much to AFAR for the very generous sponsor of our work on chromatin of centenarians during the year 2021-2022.
Simone gives a virtual seminar at the University of Pennsylvania on 3D cell models for studying accessible heterochromatin.
January 2021
Dr. Ying Ge (lab link) gives a talk at our Department Seminar Series. Thank you for accepting our invitation and sharing with us your amazing science on top-down proteomics!
Simone is elected as member of the Senate Council at Einstein.
Congratulations to Eddie for his collaboration published in Nature! (link)
We have a new section: open positions! (link)
The Sidoli lab is on Google Business (see below)
Kristen Jew joins the lab as rotation student. Welcome to the team!
A collaboration with Joshua Mayoral and the lab of Louis Weiss investigating the Toxoplasma phosphatase PPM3C is published in PLoS Pathogens (link).