Welcome to the sidoli lab

We study how proteins and chromatin shape cellular identity, aging, and disease.

Although most cells in our body share the same DNA, they have very complex diversity. Individual cells can adopt distinct functional states that influence tissue function, response to therapy, and the development of age-related conditions. Our goal is to understand this hidden biological diversity by measuring proteins and chromatin directly.

To achieve this, we develop and apply cutting-edge mass spectrometry technologies, including single-cell proteomics and single-cell chromatin analysis. By combining experimental innovation, computational biology, and artificial intelligence, we investigate how molecular differences between cells emerge, evolve, and contribute to health across the lifespan.

Our work spans chromatin biology, aging research, proteomics technology development, and advanced cellular models, with the long-term goal of understanding biological systems one cell at a time.

May 2026

All news

Welcome back to the team to Charlotte Thomas!! She is joining the Sidoli lab to do her PhD with us.

Welcome also to Ertan Kastrat! He will join our lab as a postdoc after his PhD experience at CUNY. He will work with small molecules thanks to the K12 grant that our institute received. Thank you to Dr. Johanna Daily for including us in this great initiative.

Welcome as well to Hulyana Brum! Hulyana is a student from the Carlos Chagas Institute - Fiocruz Parana (Curitiba, Brazil). She is coming to do part of her PhD at Einstein. Thanks to the collaboration with Dr. Daniel Zamith Miranda and her experience with proteomics, she will have her desk in our lab!

Congratulations to Ronnie for becoming officially a Doctor of Philosophy! The Commencement was very inspiring. Great things ahead!

Also, well done to Ronnie for giving a great webinar for Scienion on single cell histone analysis! (link)

Other great news coming up! Sarah has officially scheduled her PhD thesis defense. It is on July 7th! The same day, we will also have a seminar of Dr. Jessica Tyler (Cornell), her external committee member.

Simone returns from the Bollum Symposium (Minneapolis, Minnesota) and the MDS Symposium (MD Anderson, Houston, Texas). Thank you so much to Drs. Amy Hauck and Simona Colla for the invite, respectively!

Great work to Ronnie and Max who secured a collaboration with Phylo (Biomni Lab) to work on new prompts for single-cell proteomics data analysis using AI.

Latest images

All images

Problem no. 1327 in proteomics: when you do not get data from your mass spec, check the inlet 😰😭😢

Summer 🐿️🐿️🐿️🐿️🐿️

As they say, it’s a wrap from ASMS!! Thank you guys for presenting our science to the world, and thank you to all the friends and colleagues who interacted with us 💕💕💕💕

Ronnie’s turn to amaze the ASMS community with his single cell chromatin work!! 🧬🧬🧬🧬

Max only needs one arm to present his poster 💪💪💪💪 ASMS 2026!!!

ASMS 2026!!! Pictures coming 📸📸📸📸📸 Giulia explains her poster to a very tall guy 😊😊😊

Jenny received “another” PhD 😂😂😂

Looking good in academic regalia with Drs. Libusha Kelly and Gregoire Lavau. What a commencement!! 🎓🎓🎓

Congratulations to our star Ronnie! 🎉🎉🎉 This week, he got hooded for his PhD and he is officially a Doctor of Philosophy!

A full house for Jenny’s lunch and learn, teaching laser capture microdissection 😍😍😍 Thank you Leica for organizing it!

A final picture from the MD Anderson symposium! What a community you are bringing together, Dr. Simona Colla 😍😍😍

What an experience presenting at the Bollum symposium (University of Minnesota)!! Thank you so much for the invite to the amazing organizers Drs. Amy Hauck, Kanishk Jain, and Juan Carlos Rivera-Mulia ❤️❤️❤️

We are getting a brand new -80 freezer!! Thank you so much to Dr. Maureen Charron for the generous donation ❤️❤️❤️

Our book will spend a few days in the Einstein Hall of Fame 📚📚📚📚😊😊😊

The 2026 NYCTrainKUHR Retreat spotlighted career development, patient-engaged research priorities, and dynamic panels with experts from basic/clinical science, government, education, pharma, biotech startups, cores, and administration. Thank you for the invite for the career discussion, Mike Ross!