Welcome to the sidoli lab
We study how proteins and chromatin shape cellular identity, aging, and disease.
Although most cells in our body share the same DNA, they have very complex diversity. Individual cells can adopt distinct functional states that influence tissue function, response to therapy, and the development of age-related conditions. Our goal is to understand this hidden biological diversity by measuring proteins and chromatin directly.
To achieve this, we develop and apply cutting-edge mass spectrometry technologies, including single-cell proteomics and single-cell chromatin analysis. By combining experimental innovation, computational biology, and artificial intelligence, we investigate how molecular differences between cells emerge, evolve, and contribute to health across the lifespan.
Our work spans chromatin biology, aging research, proteomics technology development, and advanced cellular models, with the long-term goal of understanding biological systems one cell at a time.
July 2026
Congratulations to Sarah for defending her PhD!!! Fantastic presentation, defense, and party! We are really happy we have another doctor in the team; this one is PhD #4! Also, thank you so much to Dr. Jessica Tyler (Cornell) who very kindly agreed to be in the defense committee and gave an amazing seminar at Einstein.
Great performance of the Sidoli lab at the Single-Cell Proteomics Conference in Boston. We had three oral presentations from Giulia, Max and Ronnie. Jenny and Carlos participated as well, with lots of interest for their single-cell service. Our pictures from the conference are available here (link)!
Summer party? Check! Thank you everyone for making our barbecue (and baby shower!!!!) a great success and really fun! Here are some pictures (link).
The lab participates to the New York City Chromatin Club Symposium. Thank you to Stephanie and Charlotte for participating, and to Sarah for presenting a poster!
Another international on her way to the Sidoli lab! Welcome to Palena Pinto, who will join us in September for 6 months! Palena is a PhD student in the Dentistry Program at Universidade CEUMA, São Luís, Maranhão, Brazil.
The lab receives funding from our new aging institute, the BIO-VITAL center. Thank you so much to the Chairs for including our proteomics team!
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